[ad_1]
Binnewies, M. et al. Understanding the tumor immune microenvironment (TIME) for efficient remedy. Nat. Med. 24, 541–550 (2018).
Thorsson, V. et al. The immune panorama of most cancers. Immunity 48, 812–830 (2018).
Li, X. et al. The immunological and metabolic panorama in major and metastatic liver most cancers. Nat. Rev. Most cancers 21, 541–557 (2021).
Marquardt, J. U., Andersen, J. B. & Thorgeirsson, S. S. Practical and genetic deconstruction of the mobile origin in liver most cancers. Nat. Rev. Most cancers 15, 653–667 (2015).
Finn, R. S. et al. Atezolizumab plus bevacizumab in unresectable hepatocellular carcinoma. N. Engl. J. Med. 382, 1894–1905 (2020).
Coffelt, S. B., Wellenstein, M. D. & de Visser, Okay. E. Neutrophils in most cancers: impartial no extra. Nat. Rev. Most cancers 16, 431–446 (2016).
Jaillon, S. et al. Neutrophil range and plasticity in tumour development and remedy. Nat. Rev. Most cancers 20, 485–503 (2020).
Shaul, M. E. & Fridlender, Z. G. Tumour-associated neutrophils in sufferers with most cancers. Nat. Rev. Clin. Oncol. 16, 601–620 (2019).
Ng, L. G., Ostuni, R. & Hidalgo, A. Heterogeneity of neutrophils. Nat. Rev. Immunol. 19, 255–265 (2019).
Quail, D. F. et al. Neutrophil phenotypes and features in most cancers: a consensus assertion. J. Exp. Med. 219, e20220011 (2022).
Cui, C. et al. Neutrophil elastase selectively kills most cancers cells and attenuates tumorigenesis. Cell 184, 3163–3177 (2021).
Ponzetta, A. et al. Neutrophils driving unconventional T cells mediate resistance towards murine sarcomas and chosen human tumors. Cell 178, 346–360 (2019).
Yang, L. et al. DNA of neutrophil extracellular traps promotes most cancers metastasis by way of CCDC25. Nature 583, 133–138 (2020).
Szczerba, B. M. et al. Neutrophils escort circulating tumour cells to allow cell cycle development. Nature 566, 553–557 (2019).
Zhang, Q. et al. Panorama and dynamics of single immune cells in hepatocellular carcinoma. Cell 179, 829–845(2019).
Sharma, A. et al. Onco-fetal reprogramming of endothelial cells drives immunosuppressive macrophages in hepatocellular carcinoma. Cell 183, 377–394 (2020).
Ma, L. et al. Single-cell atlas of tumor cell evolution in response to remedy in hepatocellular carcinoma and intrahepatic cholangiocarcinoma. J. Hepatol. 75, 1397–1408 (2021).
Ma, L. et al. Tumor cell biodiversity drives microenvironmental reprogramming in liver most cancers. Most cancers Cell 36, 418–430 (2019).
Solar, Y. et al. Single-cell panorama of the ecosystem in early-relapse hepatocellular carcinoma. Cell 184, 404–421 (2021).
Zheng, C. et al. Panorama of infiltrating t cells in liver most cancers revealed by single-cell sequencing. Cell 169, 1342–1356 (2017).
Zhang, M. et al. Single-cell transcriptomic structure and intercellular crosstalk of human intrahepatic cholangiocarcinoma. J. Hepatol. 73, 1118–1130 (2020).
Aizarani, N. et al. A human liver cell atlas reveals heterogeneity and epithelial progenitors. Nature 572, 199–204 (2019).
Xie, X. et al. Single-cell transcriptome profiling reveals neutrophil heterogeneity in homeostasis and an infection. Nat. Immunol. 21, 1119–1133 (2020).
Zilionis, R. et al. Single-cell transcriptomics of human and mouse lung cancers reveals conserved myeloid populations throughout people and species. Immunity 50, 1317–1334 (2019).
Ballesteros, I. et al. Co-option of neutrophil fates by tissue environments. Cell 183, 1282–1297 (2020).
Bagaev, A. et al. Conserved pan-cancer microenvironment subtypes predict response to immunotherapy. Most cancers Cell 39, 845–865 (2021).
Zhang, L. et al. Single-cell analyses inform mechanisms of myeloid-targeted therapies in colon most cancers. Cell 181, 442–459 (2020).
Kiss, M. et al. IL1β promotes immune suppression within the tumor microenvironment impartial of the inflammasome and gasdermin D. Most cancers Immunol. Res. 9, 309–323 (2021).
Feig, C. et al. Focusing on CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic most cancers. Proc. Natl Acad. Sci. USA 110, 20212–20217 (2013).
Most cancers Genome Atlas Analysis Community. Complete and integrative genomic characterization of hepatocellular carcinoma. Cell 169, 1327–1341 (2017).
Farshidfar, F. et al. Integrative genomic evaluation of cholangiocarcinoma identifies distinct IDH-mutant molecular profiles. Cell Rep. 18, 2780–2794 (2017).
Xue, R. et al. Genomic and transcriptomic profiling of mixed hepatocellular and intrahepatic cholangiocarcinoma reveals distinct molecular subtypes. Most cancers Cell 35, 932–947 (2019).
Wu, R. et al. Complete evaluation of spatial structure in major liver most cancers. Sci. Adv. 7, eabg3750 (2021).
Xiang, X. et al. IDH mutation subgroup standing associates with intratumor heterogeneity and the tumor microenvironment in intrahepatic cholangiocarcinoma. Adv. Sci. 8, e2101230 (2021).
Wu, S. Z. et al. A single-cell and spatially resolved atlas of human breast cancers. Nat. Genet. 53, 1334–1347 (2021).
Ramachandran, P., Matchett, Okay. P., Dobie, R., Wilson-Kanamori, J. R. & Henderson, N. C. Single-cell applied sciences in hepatology: new insights into liver biology and illness pathogenesis. Nat. Rev. Gastroenterol. Hepatol. 17, 457–472 (2020).
Wculek, S. Okay. & Malanchi, I. Neutrophils help lung colonization of metastasis-initiating breast most cancers cells. Nature 528, 413–417 (2015).
Boivin, G. et al. Sturdy and managed depletion of neutrophils in mice. Nat. Commun. 11, 2762 (2020).
Remmerie, A. et al. Osteopontin expression identifies a subset of recruited macrophages distinct from kupffer cells within the fatty liver. Immunity 53, 641–657 (2020).
Guilliams, M. et al. Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches. Cell 185, 379–396 (2022).
Zhu, A. X. et al. Molecular correlates of scientific response and resistance to atezolizumab together with bevacizumab in superior hepatocellular carcinoma. Nat. Med. 28, 1599–1611 (2022).
Seehawer, M. et al. Necroptosis microenvironment directs lineage dedication in liver most cancers. Nature 562, 69–75 (2018).
Satija, R., Farrell, J. A., Gennert, D., Schier, A. F. & Regev, A. Spatial reconstruction of single-cell gene expression knowledge. Nat. Biotechnol. 33, 495–502 (2015).
Wolf, F. A., Angerer, P. & Theis, F. J. SCANPY: large-scale single-cell gene expression knowledge evaluation. Genome Biol. 19, 15 (2018).
Puram, S. V. et al. Single-cell transcriptomic evaluation of major and metastatic tumor ecosystems in head and neck most cancers. Cell 171, 1611–1624 (2017).
Muhl, L. et al. Single-cell evaluation uncovers fibroblast heterogeneity and standards for fibroblast and mural cell identification and discrimination. Nat. Commun. 11, 3953 (2020).
Aran, D. et al. Reference-based evaluation of lung single-cell sequencing reveals a transitional profibrotic macrophage. Nat. Immunol. 20, 163–172 (2019).
Vento-Tormo, R. et al. Single-cell reconstruction of the early maternal-fetal interface in people. Nature 563, 347–353 (2018).
Gulati, G. S. et al. Single-cell transcriptional range is a trademark of developmental potential. Science 367, 405–411 (2020).
Qiu, X. et al. Single-cell mRNA quantification and differential evaluation with Census. Nat. Strategies 14, 309–315 (2017).
Lange, M. et al. CellRank for directed single-cell destiny mapping. Nat. Strategies 19, 159–170 (2022).
Aibar, S. et al. SCENIC: single-cell regulatory community inference and clustering. Nat. Strategies 14, 1083–1086 (2017).
Welch, J. D. et al. Single-cell multi-omic integration compares and contrasts options of mind cell id. Cell 177, 1873–1887 (2019).
Schürch, C. M. et al. Coordinated mobile neighborhoods orchestrate antitumoral immunity on the colorectal most cancers invasive entrance. Cell 182, 1341–1359 (2020).
Fan, Y. et al. Focusing on a number of cell dying pathways extends the shelf life and preserves the operate of human and mouse neutrophils for transfusion. Sci. Transl. Med. 13, eabb1069 (2021).
[ad_2]